• After deployment of the second

  2018-10-22

  

  After deployment of the second SEMS, esophagography (Fig. 3) and bronchoscopy (Fig. 1B) were performed again and showed no signs of TE fistula recurrence. The patient complained of neck pain, but the patient became capable of oral intake again. The patient died 4 months after placement of the second

• br mtDNA mutation in human cancers Several

  2018-10-22

  

  mtDNA mutation in human cancers Several authors have evaluated not only the quantitative change in mtDNA copy number, but also the qualitative mtDNA D-loop mutations in human cancers. D-loop mutations, including the D310 region, have been reported in prostate cancer, head and neck cancer, lung ca

• Introduction An estimated of wastewater in developing countr

  2018-10-22

  

  Introduction An estimated 90% of wastewater in developing countries undergoes no treatment (Corcoran et al., 2010). For example in Kumasi, Ghana, only 8% of the wastewater undergoes some form of treatment (Keraita et al., 2002), while the remaining raw sewage flows to wetlands linked to small strea

• Introduction Rheumatoid arthritis RA is

  2018-10-22

  

  Introduction Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease, affecting freely movable joints, such as hand, knee and shoulder joints. The symptoms of active RA include pain, swelling, morning stiffness, warmth, redness, and limits in the functions of the joints. The system

• Introduction The intestinal tract of adult carries kg of

  2018-10-22

  

  Introduction The intestinal tract of adult carries 1–2kg of microbes. It is a common knowledge that pathogenic microbes could cause infectious diseases such as diarrheal, while others are associated with inflammatory and allergic diseases [1–3]. On the other hand, the majority of the gut microbes

• Research into embryogenesis and nervous system

  2018-10-22

  

  Research into embryogenesis and nervous system development has been instrumental to the identification of factors required for cell specification. Using information gleaned from these studies, many groups have developed induction protocols to instruct hESCs and iPSCs to become a variety of neural ce

• br Material and methods br Acknowledgment The authors would

  2018-10-22

  

  Material and methods Acknowledgment The authors would like to thank Mr. Chee Peng Ng (Institute of Molecular and Cell Biology, Singapore) for his help on the electron scanning microscope and Dr. William Birch (Institute of Materials Research and Engineering, Singapore) for his critical review

• Therefore a major goal remains to understand the complex cel

  2018-10-22

  

  Therefore, a major goal remains to understand the complex cellular and molecular network that controls HSC generation and expansion. In fact, HSCs that are mainly slow cycling (Wilson et al., 2008) and reside in the bone marrow during the entire life of an individual, are not generated there. They a

• The increasing number of studies focusing

  2018-10-22

  

  The increasing number of studies focusing on regenerative medicine and stem cell transplantation is being accompanied by the development of techniques using many types of nanoparticles. The combination of nanotechnology with stem cell research may be able to address some challenges in this research

• br Results br Discussion In this study

  2018-10-22

  

  Results Discussion In this study, we identified altogether 21 novel imprinted DMRs, including a novel class of intergenic DMRs, which reside in regions with no apparent imprinted ABT-263 in PSCs. This class of imprinted DMRs either may regulate genes in a tissue-specific manner, thus adding t

• PLX-4720 Although our work with BRCA mutant iPSCs

  2018-10-22

  

  Although our work with BRCA1 mutant iPSCs led to our investigation of PKC-theta upregulation in human breast tumors, future studies will be necessary to validate whether PKC-theta can be used as a biomarker or therapeutic target in BRCA1 mutant tumors. Because the frequency of BRCA1 mutations in pat

• br Materials and methods br Results br Discussion To evaluat

  2018-10-22

  

  Materials and methods Results Discussion To evaluate the effects of proNGF on NSC proliferation, we performed cell viability assay, BrdU incorporation assay and neurosphere assay. Our results showed that proNGF significantly reduced the total number of viable cells and the proportion of Brd

• In this study localization of the SSC population

  2018-10-22

  

  In this study, localization of the SSC population was determined by PGP 9.5 expression. PGP 9.5, also called ubiquitin C-terminal hydrolase L-1, is expressed in neuronal erk pathway and testes, and specific expression of PGP9.5 was identified in spermatogonia of day 8 and 16 mice, and PGP9.5 express

• br Materials and methods br Results br Discussion

  2018-10-20

  

  Materials and methods Results Discussion Strategies aiming at controlled divergence of ASCs to specific differentiated cell types essentially rely on prolonged culture in the presence of specific sets of growth factors and/or matrix proteins (Zuk et al., 2001). Specific culture conditions w

• In this study we were able to successfully delete

  2018-10-20

  

  In this study, we were able to successfully delete Klf5 from the Lgr5-expressing intestinal stem ibuprofen msds in adult mice. The short-term effect of Klf5 deletion in the intestinal and colonic stem cells was a gradual disappearance of Klf5 expression starting in the EGFP-positive stem cells and m

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