• Regarding FMR transcription by FXS HESCs we show that FMR

  2018-11-02

  

  Regarding FMR1 transcription by FXS HESCs, we show that FMR1 expression in unmethylated FXS HESCs (HEFX, 0% methylation) is indistinguishable from WT HESCs and is significantly reduced in all methylated FXS cell lines. Nevertheless, the relation between the extent of methylation and FMR1 expression

• Whereas most studies aiming at reprogramming brain resident

  2018-11-02

  

  Whereas most studies aiming at reprogramming brain-resident glia into neurons focused on astroglia, NG2 glia represent an interesting alternative cellular source given their abundance and life-long capacity for proliferation (Dimou and Götz, 2014). Here, we found that ∼60% of the induced DCX+ neuron

• Here we study the impact of the common

  2018-11-02

  

  Here we study the impact of the common GBA-N370S mutation on the phenotype of patient-specific dopaminergic neuronal cultures differentiated from iPSC lines derived from patients with PD and identify deficits in protein homeostasis. Our results suggest that the heterozygous GBA-N370S mutation leads

• br Experimental Procedures See also Supplemental Experimenta

  2018-11-02

  

  Experimental Procedures See also Supplemental Experimental Procedures. Author Contributions Acknowledgments We thank Dr. Yun Deng for providing Tg (myl7:EGFP) zebrafish, Dr. Niels C. Bols and Dr. Peng Hu for their technical support with zebrafish. This work was supported by the National Na

• Introduction The mammalian respiratory tract

  2018-11-02

  

  Introduction The mammalian respiratory tract is normally maintained by abundant progenitors that differ in molecular phenotype, differentiation potential, and regulation between airway regions along the proximodistal axis (Hogan et al., 2014; Rackley and Stripp, 2012). Basal cells maintain the pseu

• spleen tyrosine kinase In the present study we demonstrated

  2018-11-02

  

  In the present study, we demonstrated the potential of hiPSC-CMs to reflect an adverse drug response in healthy individuals. However, as mentioned above, studies in larger cohorts of individuals and using various types of drugs will be required to translate this spleen tyrosine kinase potential int

• Functional analysis has shown that miR p promotes the differ

  2018-11-02

  

  Functional analysis has shown that miR-342-5p promotes the differentiation of NSCs into INPs. Upregulation of miR-342-5p in cultured NS/PCs in vitro leads to reduced neurosphere formation and colony formation in the floating culture system and adherent culture system, respectively. Clonal analysis i

• There are different methods of random

  2018-11-02

  

  There are different methods of random function representation, e.g. using the generalized Fourier series, the methods of Karhunen et al. . For any random function, these methods allow to construct an infinite functional series with coefficients that are normalized uncorrelated random quantities. All

• LY3009104 Thus the calculated Navier Stokes

  2018-11-02

  

  Thus, the calculated Navier–Stokes equations for an incompressible conducting fluid which include the density of the EM field force as the driving force can be expressed in the following way in differential form: Here μ is the effective viscosity, defined as the sum of the laminar and the turbule

• paf receptor The first one consisted of a combination of a m

  2018-11-02

  

  The first one consisted of a combination of a 0.5-mm-thick polyethylene filter at the entrance of the silicon bolometer and a 6-µm-thick multilayer Mylar beam splitter. This optical configuration allowed to perform measurements in the photon paf receptor range from 4 to 40meV. The second configura

• One possible reason why lasing characteristics deteriorate a

  2018-11-02

  

  One possible reason why lasing characteristics deteriorate at high injection levels in materials with a low band gap may be non-radiative Auger recombination, which can have a resonant character under certain conditions, leading to a marked increase in the recombination rate [3]. Studying the recomb

• Parks serve as destinations for dog walkers

  2018-11-02

  

  Parks serve as destinations for dog-walkers, and dog-walking routines support physical activity (Cutt, Giles-Corti, Knuiman & Burke, 2007; Christian et al., 2013). Dogs may provide motivation for people to remain active, when built environment (e.g., low walkability) and weather conditions might oth

• The notion that pets can facilitate social capital goes

  2018-11-02

  

  The notion that pets can facilitate social capital goes beyond the more commonly investigated role of pets as a social icebreaker between strangers, or as a catalyst for social interaction (Hunt, Hart, & Gomulkiewicz, 1992; McNicholas & Collis, 2000; Messent, 1983; Newby, 1997; Robins, Sanders, & Ca

• br Conclusions br Conflict of interest

  2018-11-02

  

  Conclusions Conflict of interest Acknowledgements: This work was funded by FORTE (Swedish Research Council for Health, Working Life and Welfare; Grant numbers 2013-1269 and 2012-0979), and the Medical Faculty at Lund University. These institutions had no involvement regarding the collection

• The diagnosis of OSAS is one of the key problems

  2018-11-02

  

  The diagnosis of OSAS is one of the key problems in this field. Although polysomnography is considered as the gold standard for the diagnosis of OSAS [1], this method is not yet widely available due, probably, to its high cost. Thus, some attempts have been made to develop self-report measures based

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