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br Materials and methods br
2020-05-25
Materials and methods Acknowledgments This research was supported by funding from University of California Irvine to H.U.B. Introduction Oral squamous cell carcinoma (OSCC) is the fourth major cause of mortality among men in Taiwan and its incidence rates continue to rise annually. OSCC is
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The IV chains of mature GBM are built exclusively
2020-05-22
The α3/α4/α5(IV)-chains of mature GBM are built exclusively by podocytes (not by endothelial cells) (Abrahamson et al., 2009), placing the podocytes into the focus of GBM-diseases such as Alport syndrome. Alport syndrome (AS) is caused by mutations in the COL4A3, 4 or 5 genes coding for the α3/α4/α5
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Table shows the clinical data of recipients with CYP
2020-05-22
Table 2 shows the clinical data of 23 recipients with CYP3A5*1 allele classified by the presence or absence of CYP3A phenoconversion. Phenoconversion of CYP3A was observed in 10 recipients with CYP3A5*1 allele. No significant differences in eGFR, ALT and total bilirubin were observed between recipi
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The significance of the two biomarkers
2020-05-22
The significance of the two biomarkers for the detection of Aspergillus antigen and DNA in the sputum of patients cannot be over-emphasised. The mean GMI value was higher among CPA patients than the ABPA. This might not be unconnected with the fact that CPA is associated with lung damage and pre-exi
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In frame exon skipping of COL A has been suspected
2020-05-22
In frame exon 41 skipping of COL6A3 has been suspected to be responsible for isolated dystonia in several human kindreds without muscular defects [94]. In order to validate their hypothesis, the authors used zebrafish to selectively knock down several exons in col6a3 and found a negative impact on m
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br Acknowledgements This work was supported by National Natu
2020-05-22
Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec
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In particular EphB has been one of the
2020-05-22
In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer Aloperine in vitro and in vivo. Inhibition of EphB4 signalling u
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Our observation that nuclear but not cytoplasmic EP expressi
2020-05-22
Our observation that nuclear, but not cytoplasmic EP4 expression is associated with different outcomes is interesting. In breast cancer, using the same methods, we did not detect EP4 in the nucleus of malignant amprolium whereas cytoplasmic EP4 was commonly observed [13]. While G protein-coupled re
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br Introduction DNA ligation is required during DNA replicat
2020-05-22
Introduction DNA ligation is required during DNA replication and to complete almost all DNA repair events. In human cells, the DNA ligases encoded by three LIG genes are responsible for joining interruptions in the phosphodiester backbone [1]. These enzymes have distinct but overlapping functions
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WIN 18446 In summary our findings show
2020-05-22
In summary, our findings show that LPS can activate CysLT2R on microglial WIN 18446 to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via suppression of LPS-
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br Materials and methods br Results
2020-05-22
Materials and methods Results and discussion Acknowledgements This study was supported by the Open Project Program of the Key Laboratory of Mariculture & Enhancement of Zhejiang Province (No. 2016KF003), the Key Project of Zhejiang Province (No. 2016C02055-7), and the International Science
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br Materials and methods br Acknowledgements We thank Drs
2020-05-22
Materials and methods Acknowledgements We thank Drs. Nathan Sherer (University of Wisconsin-Madison) and Bryan Cullen (Duke University) for generous reagent gifts. The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: HIV-2ROD phage from Dr. Ron
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Primases are classified into two
2020-05-21
Primases are classified into two major groups: first, the DnaG primases, found in bacteria and bacteriophages, and second, the archaeoeukaryotic primases. Remarkably, bacterial and archaeoeukaryotic primases have no structural similarity and, presumably, evolved independently (Leipe et al., 1999). T
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SB 265610 mg Funding sources This study was funded by Europe
2020-05-21
Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg
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The sequence identity of CYP A
2020-05-20
The sequence identity of CYP3A163 with CYP3A sequences from other species is maximum in reptiles ranging (75-91)%, gradually decreasing from pde-5 inhibitors (63-71)% to mammals 62% to downwards based on evolutionary distances. The high level of homology with CYP3A77 in Alligator mississippiensis s
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