• Knock out mice of FXR

  2021-12-21

  

  Knock-out mice of FXR showed enhancing cholesterol metabolism in vivo and reducing serum levels of total cholesterol. Additionally, the results of FXR-deficiency mice revealed potential effects on the improvement of obesity and diabetes.19, 20 As a natural FXR ligand, guggulsterone possesses antagon

• mln4924 To investigate an involvement of GPR and GPR in

  2021-12-21

  

  To investigate an involvement of GPR120 and GPR40 in the enhancement of cell motile activity of MG-63 cells, highly migratory (MG63-R7) mln4924 were established from MG-63 cells (Fig. 2A). The expression level of GPR120 gene was significantly higher in MG63-R7 cells than in MG-63 cells, while no ch

• Focal adhesion kinase FAK also known as protein

  2021-12-21

  

  Focal adhesion kinase (FAK), also known as protein tyrosine kinase2 (PTK2), is a tyrosine kinase and vital member in integrin-mediated signaling pathways [3]. In response to integrin involvement, FAK would be phosphorylated. It was reported that FAK is involved in cellular adhesion and spreading [4]

• The combination of HIV antigen

  2021-12-20

  

  The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window AMD3100 8HCl for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo assay has

• br Significance Cellular heterogeneity for phenotypic featur

  2021-12-20

  

  Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het

• SP2509 An interference of fluorescence derived from

  2021-12-20

  

  An interference of fluorescence derived from biological samples is also an important SP2509 to be addressed in the fluorescent analysis for biological samples. Advanced glycation endproducts (AGEs) are representative endogenous fluorescent substances that are widely distributed in various organs as

• AR-M 1896 br Materials and methods br Results

  2021-12-20

  

  Materials and methods Results Discussion Serum HBsAg is not only an important serological marker for the screening and diagnosis of HBV infection but also an important indicator for the treatment of hepatitis B [15]. Jaroszewicz et al. [4] and Nguyen et al. [8] reported that the HBsAg level

• br Discussion The aminoglycoside antibiotic gentamicin conti

  2021-12-20

  

  Discussion The aminoglycoside antibiotic gentamicin continues to be an important agent against life threatening infections. However, nephrotoxicity is a major complication of the gentamicin administration. Thus amelioration of nephrotoxicity would enhance its clinical use. Several approaches invo

• Our results show furthermore that higher concentrations

  2021-12-20

  

  Our results show furthermore, that higher concentrations of butyric Cystamine dihydrochloride additionally affect GSTP1 mRNA stability leading to a strongly reduced half-life. Concentration-dependent effects of butyric acid on RNA stability and cell signaling pathways involved in the regulation of G

• Several studies have sought a cross relationship between com

  2021-12-20

  

  Several studies have sought a cross-relationship between commensal bacteria-derived metabolites and the Gprs (Blad et al., 2012). Gpr81 is expressed primarily in adipocytes, and hence, lactate-Gpr81 interaction inhibits lipolysis (Cai et al., 2008, Liu et al., 2009). Lactate reduced inflammation by

• br Conclusion The wild study

  2021-12-20

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and AACOCF3 synthesis plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher novelty pr

• br Methods br Results br Discussion Among three

  2021-12-20

  

  Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc

• br The GLI code The GLI code

  2021-12-20

  

  The GLI code The GLI code model [21], [22] considers the total GLI function as a balance of positive activator (GLIA) and negative repressive (GLIR) activities with GLI1 being mostly a positive transcription factor and GLI3 mostly a transcriptional repressor. The GLIA:GLIR ratio is thus critical,

• LPCs have been previously described as potential anti diabet

  2021-12-20

  

  LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al

• adrenergic antagonist A previous study from our institution

  2021-12-20

  

  A previous study from our institution showed moderate correlation between the APTT and Anti-FXa assays, prompting an institution-wide change to an Anti-FXa based monitoring of unfractionated heparin. The current study is a descriptive analysis to evaluate the clinical outcomes in this pediatric coho

15170 records 454/1012 page Previous Next First page 上5页 451452453454455 下5页 Last page