• Solid tumors usually present insufficient supply of oxygen a

  2022-02-14

  

  Solid tumors usually present insufficient supply of oxygen, activating the hypoxia inducible factor-1 (HIF-1) pathway, which prompts an adaptive response on genes that regulate glycolytic metabolism, promoting glucose uptake through the transcription of GLUTs [54]. Increasing evidence indicates that

• Gastric inhibitory polypeptide a hormone belonging to

  2022-02-14

  

  Gastric inhibitory polypeptide, a hormone belonging to the glucagon-secretin family of peptides, exhibits protection against the neurodegeneration and also stimulates neurogenesis in adult rats in a paracrine manner (Gault and Holscher, 2008, Nyberg et al., 2005, Usdin et al., 1993). The expression

• Similarly Somavarapu and Kepp constructed a

  2022-02-14

  

  Similarly, Somavarapu and Kepp [29] constructed a PS1 homology model using 4HYG as a template, plus modeling the TM6-TM7 intracellular segment (amino acids 273 to 374). In this study, the authors considered for the first time the mature and immature (not autoproteolyzed) forms of PS1 component, sinc

• Optimization of the tetrahydroindazole series led to the

  2022-02-14

  

  Optimization of the tetrahydroindazole series led to the discovery of two moderately potent γ-secretase modulators, 2-cyclobutane and 2-hydroxy-2-methylpropane which were subsequently evaluated in a kinetic aqueous solubility assay. Unfortunately, neither analog demonstrated improved solubility ().

• Compounds were tested for GPR

  2022-02-14

  

  Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO Cy5 NHS ester (non-sulfonated) australia transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To e

• We reviewed the results of comprehensive genomic profiling C

  2022-02-14

  

  We reviewed the results of comprehensive genomic profiling (CGP) in 26,054 cases of NSCLC and examined the frequency and clinical characteristics of patients whose tumors harbor FGFR fusions. To our knowledge, this is the most in-depth evaluation of FGFR fusions exclusively in NSCLC. Here we will de

• The molecular target of N BPs

  2022-02-14

  

  The molecular target of N-BPs is farnesyl diphosphate synthase (FPPS), a crucial enzyme at the branch point of cholesterol and isoprenoid synthesis in the mevalonate pathway [5]. Because they bind calcium ions, N-BPs accumulate quickly in the skeleton and are internalised by osteoclasts, leading to

• Allergic rhinitis characterized by inflammation of

  2022-02-12

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to D-Pantothenic acid in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering all

• Furthermore a direct thiol protective role of S

  2022-02-12

  

  Furthermore, a direct thiol protective role of S-nitrosylation has been reported in animals [66]. Here, formation of higher order irreversible oxidative modifications, such as sulfinic and sulfonic acids were prevented by S-nitrosylation. All these observations underline the important role of ROS in

• The following are the supplementary

  2022-02-12

  

  The following are the supplementary data related to this article. Authorship SLC and CGE performed the study conception and experimental design, wrote the paper and directed the activities of this work. ESM and JICA performed most of the degranulation assays, [Ca2+] measurements regarding to the

• br Introduction In the treatment of patients with AIDS

  2022-02-12

  

  Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s

• Overall the multiple nucleic acid hybridization

  2022-02-12

  

  Overall, the multiple nucleic HPF synthesis hybridization method is useful for detecting specific transcripts within tissues of nematodes. The present study suggests that Peq-pgp-11 and Peq-pgp-16 mRNAs are expressed in many tissues of Parascaris. Our results indicate that Pgps could protect nemato

• Insulin de sensitization has been observed

  2022-02-12

  

  Insulin de-sensitization has been observed in the brains of people with AD [51], [52], [53] and we previously demonstrated that the GLP-1 analogue liraglutide was able to reverse this [54]. Importantly, ask1 inhibitor insulin de-sensitization correlates well with cognitive decline [15], [55] and wi

• br Conclusion and future directions GS is

  2022-02-12

  

  Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS

• Retinal GAL receptor distribution suggests

  2022-02-12

  

  Retinal GAL receptor distribution suggests an intrinsic neuronal control since retina lacks an autonomic innervation, and a signal modulation seems most likely here, acting via GALR1 while GALR2 and GALR3 seem to play a rather minor role in this signal transduction. While sources acting on these ret

15170 records 422/1012 page Previous Next First page 上5页 421422423424425 下5页 Last page