• All these recent results show the interconnection between th

  2022-05-12

  

  All these recent results show the interconnection between the Hippo pathway as a tumor-suppressor on the one hand and its function as regulator of metabolic homeostasis on the other. Disruption of the Hippo pathway leads to cancer growth, which is often associated with pathological disturbances in t

• dna alkylating agents br Conflict of interest br Funding Thi

  2022-05-12

  

  Conflict of interest Funding This work was supported by the National Institutes of Health MSK Cancer Center Support Grant/Core Grant [P30 CA008748]. The funding source had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report;

• In the Hedgehog signaling pathway cholesterol is required to

  2022-05-12

  

  In the Hedgehog signaling pathway, cholesterol is required to activate SMO (Cooper et al., 2003), the downstream target of PTCH1. A previous study (Bidet et al., 2011) reported that Patched expression in yeast TBB mg increased extrusion of a fluorescent boron dipyromethanene sterol derivative (BODI

• br Discussion By using ultra deep sequencing

  2022-05-12

  

  Discussion By using ultra-deep sequencing, we conducted a thorough assessment of HCV-NS3 protease variants in chronic PI-naïve patients infected with HCV-1a and HCV-1b under telaprevir-based triple therapy at baseline and after 4weeks of treatment. Several synonymous and non-synonymous substitut

• The relationship between estrogen and the Hedgehog

  2022-05-11

  

  The relationship between estrogen and the Hedgehog pathway as well as the associated mechanism have already been investigated in many tissues, especially in breast cancer (Chang et al., 2012, Katayama et al., 2006, Ramaswamy et al., 2012). Hitherto, even though we have proved that HH-Gli pathway pro

• IL-2, human recombinant It is generally considered that elev

  2022-05-11

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet IL-2, human recombina

• AT-101 br Voltage dependent anion channel VDAC is a

  2022-05-11

  

  Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially

• In summary metagenome sequencing of paddy soil was performed

  2022-05-11

  

  In summary, metagenome sequencing of paddy soil was performed with 55.68 Gb sequences, and subsequent data mining was performed for functional profiles and metabolic pathways. Several GH family proteins, such as amylases, cellulases, xylanases, and galactosidases, were explored in the paddy soil met

• The receptor binding assay used in our previous study demons

  2022-05-11

  

  The receptor binding assay used in our previous study demonstrated that propofol competitively binds to FPR1, thus blocking the downstream signal transduction of FPR1 and inhibiting neutrophil immune activities [8]. In this study, we assessed the pharmacological action of fMMYALF in the presence of

• FPR activation stimulates multiple signal transduction pathw

  2022-05-11

  

  FPR1 activation stimulates multiple signal transduction pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, phagocytosis, Z-LEHD-FMK of secretory granules, and superoxide anion radical (O2) production, which contribute to the physiological inflammatory response asso

• In addition the interplay of membrane

  2022-05-11

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and Thalidomide induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant further r

• BMP signals play pivotal roles in

  2022-05-10

  

  BMP signals play pivotal roles in the various processes of chondrogenesis [12], [13]. At early stages of chondrogenesis, BMP signaling regulates the differentiation of mesenchymal Tamoxifen into chondrocytes via the induction of Sox9[29]. The loss of Noggin, a BMP antagonist, results in the overgro

• Multiple subsets of Breg cells in mice have been

  2022-05-10

  

  Multiple subsets of Breg cells in mice have been identified that could suppress the T cell-mediated response. However, a lack of consensus surface markers for Breg cells made it difficult to judge whether Breg cells are a special B cell subset or whether all flumethasone have an immuno-regulatory f

• The HCV NS A protease consists of two subunits NS

  2022-05-10

  

  The HCV NS3/4A protease consists of two subunits, NS3 and NS4A. NS3 comprises an N-terminal serine protease domain and a C-terminal RNA helicase domain [12]. NS4A acts as a cofactor, which ties the holoenzyme complex to an intracellular membrane compartment. The presence of the central region of NS4

• According to literature RASs V M T S Q K

  2022-05-10

  

  According to literature, RASs V36M, T54S, Q80K and R155K are considered primary resistance mutations to different PIs. RASs V36M and R155K can reduce susceptibility to recently approved PIs simeprevir, paritaprevir and grazoprevir [18], [31], [32]. T54S is associated to resistance for first-wave tel

15170 records 377/1012 page Previous Next First page 上5页 376377378379380 下5页 Last page