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In the present studies we
2022-08-08
In the present studies, we found that genistein did not antagonize fMLF-induced Ca2+ mobilization in FPR1-HL60 rilpivirine mg and human neutrophils. Thus, the previously reported inhibitory effect of genistein on fMLF-stimulated degranulation, aggregation, and reactive oxygen species (ROS) producti
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All models used here rely on WT
2022-08-08
All models used here rely on WT FGFR3, which is activated by exogenous FGF ligand to alter chondrocyte proliferation and differentiation. This approach toward modeling the aberrant FGFR signaling in cartilage differs from the actual situation in ACH or TD, where the chondrocytes are exposed to long-
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However the clinical development of was terminated
2022-08-08
However, the clinical development of was terminated in 2013 due to the concerns over liver toxicity, raising important questions regarding the long-term safety and viability of targeting GPR40 and, more specifically, about our understanding of the pharmacobiology and signaling spectrum of this rece
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The presence of FBP in
2022-08-08
The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas
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In addition to lifestyle factors
2022-08-05
In addition to lifestyle factors, genetic factors may also influence the efficacy of antineoplastic drugs in breast cancer patients.16, 17 The HER2 gene contains several single nucleotide polymorphisms (SNPs). Two of the most investigated HER2 SNPs are Ile655Val (rs1136201) and Ala1170Pro (rs1058808
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GSTP catalyzed reduction of Prdx enhances
2022-08-05
GSTP1-1 catalyzed reduction of Prdx6 enhances its peroxidase activity. Using standard NADPH/GR/GSH-coupled assays we used cell lysates from the transiently transfected Pefloxacin Mesylate to measure the influence of GSTP1 allelic variation on peroxidase activity. Specificity for detection of Prdx6
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Kaempferol-3-rutinoside Etoposide VP a semisynthetic podophy
2022-08-05
Etoposide (VP-16), a semisynthetic podophyllotoxin derivative agent, is widely used as a chemotherapic treatment for many cancers (Hande, 1998). VP-16 has been known that its activity is mediated by the interaction with topoisomerase II (an ATP-dependent nuclear enzyme) which regulates DNA topology
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br Conflict of interest br Acknowledgment
2022-08-05
Conflict of interest Acknowledgment This work was supported by National Program on Key Basic Research Project of China (No. 2013CB127305); The National Natural Science Foundation of China (No. 314020785); Hubei Provincial Creative Team Project of Agricultural Science and Technology (No. 2007-6
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br Introduction Over the past two decades
2022-08-05
Introduction Over the past two decades, the prevalence of obesity and obesity-associated metabolic diseases, such as T2D, insulin resistance, atherosclerosis and stroke, have been dramatically increased globally [1], [2], and obesity has been suggested to be the leading cause of the reduced life
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For molecules with potential for therapeutic use high potenc
2022-08-05
For molecules with potential for therapeutic use, high potency is desired, preferably in the nM or lower concentration range. However, the glycine receptor specific peptides identified with the New England Biolabs Ph.D. libraries, both in this study (Fig. 3) and by Tipps et al. (2010), acted at low
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Ajzenman et al reported improved stability and
2022-08-05
Ajzenman et al reported improved stability and postural parameters in ASD children after EAT. Other authors presented similar findings,61, 62, 63, 64 although the studies were conducted among children with CP, and reported improved muscle symmetry,, stability of the head and the trunk, motor functio
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In conclusion we have designed
2022-08-05
In conclusion, we have designed and characterized a novel series of EAAT-blockers, exemplified by (-[4-(2-bromo-4,5-difluorophenoxy)phenyl]--asparagine)—a potent, selective, competitive non-substrate inhibitor of EAAT-2. As one of the most potent and selective EAAT-2 inhibitors identified to date,
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br Acknowledgements br Introduction Galanin shows widespread
2022-08-05
Acknowledgements Introduction Galanin shows widespread distribution in the central nervous system (CNS) and peripheral nervous system (PNS) as well as in the immune, endocrine and endothelial vascular systems (Lang et al., 2007). Galanin controls diverse physiological processes such as arousal
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br Short Communication Free fatty acid receptors
2022-08-04
Short Communication Free fatty Metoprolol Succinate receptors (FFAR) play significant roles in energy metabolism (Brown et al., 2005; Ichimura et al., 2009). The receptor FFAR1 is involved in insulin secretion in humans (Meidute Abaraviciene et al., 2013). Activation of the receptor FFAR2 increa
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Our observation of LPS induced increase in the sensitivity
2022-08-04
Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary Levonorgestrel towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the possibl
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