• Furthermore stress hormones can indirectly induce DNA damage

  2024-03-06

  

  Furthermore, stress hormones can indirectly induce DNA damage, for example by altering DNA repair and transcriptional regulation of the cell cycle. It has been found that stress hormones induce the up-regulation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) and proto-oncogene cell div

• br Hyperadiponectinemia in disease conditions Other evidence

  2024-03-06

  

  Hyperadiponectinemia in disease conditions Other evidence indicates that hyperadiponectinemia does not necessarily always imply a healthy outcome. Indeed, a recent study suggested that hyperadiponectinemia occurs in various diseases. Given that the risk for AD and vascular dementia is increased i

• CEP 1347 br Author contributions br Acknowledgements We

  2024-03-06

  

  Author contributions Acknowledgements We thank Dr. Bob Hammer and the Transgenic Core Facility at UTSW for the generation of the transgenic lines, John Shelton and the Histology Core for assistance with histology and the UTSW Metabolic Core Unit for help in phenotyping. We acknowledge support

• Mast cells Mast cells are immune

  2024-03-06

  

  Mast cells. Mast MPC 6827 hydrochloride are immune cells of the myeloid lineage and are ubiquitously present in connective tissues [75]. These cells are involved in the modulation of a number of physiological functions, such as vasodilation, angiogenesis, bacterial, and parasite elimination [75]. M

• Since at least prospective cohort

  2024-02-23

  

  Since 2005, at least 14 prospective cohort studies have been conducted to clarify inconsistencies in the field, ten of which suggested a direct correlation between antibiotic use and atopy or wheezing later in life [51–60], three found no association [61–63], and one found positive association only

• At the top of the S subsite cylinder are

  2024-02-23

  

  At the top of the S1 subsite cylinder are two “cap” residues: E572 and M1034 [13]. Atomic structures of PfA-M1 have revealed important clues into potential roles for the cap residues in substrate selection. In the PfA-M1:bestatin co-crystal structure ([13]; Fig. 1), the P1 phenyl ring occupies the S

• akt inhibitor LOXs and CYPs are a series of iron containing

  2024-02-23

  

  LOXs and CYPs are a series of iron-containing enzymes that metabolize arachidonic akt inhibitor to form biologically active products, such as epoxyeicosatrienoic acids (EETs) hydroperoxyeicosatetraenoic acids (HETEs), prostaglandins, leukotrienes and thromboxanes [6]. Among these mediators, 12/15LO

• melanocortin receptor br Introduction Alzheimer s disease

  2024-02-23

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different melanocortin receptor areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and K

• First investigation of numerous membered ether

  2024-02-23

  

  First, investigation of numerous 12-14-membered ether-linked macrocycles revealed that smaller motifs were most lipophilic efficient. Compound (3) (12-membered macrocycle) exhibited good cellular potencies (ALK IC50 = 1.0 nM; ALK-L1196 M IC50 = 20 nM) and the highest LipE (4.4) with picomolar bindin

• br GMF Remodels Actin Networks at the Leading

  2024-02-23

  

  GMF Remodels Actin Networks at the Leading Edge How are the conserved activities of GMF used in vivo to regulate branched Oxaliplatin networks (e.g., at sites of endocytosis and at the leading edge) (Figure 2A,B)? In animal cells, the regulatory effects of GMF on actin networks appear to govern

• A high throughput small molecule

  2024-02-23

  

  A high-throughput small molecule ACK1 biochemical inhibition screen was performed in-house and led to the identification of 1μM inhibitor furanopyrimidine (). Further binding studies found Pexmetinib to be both ATP-competitive and reversible. Early structure-activity relationship (SAR) work was p

• br Methods and results ACE is a Canadian satellite

  2024-02-23

  

  Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric silybin spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes but also pro

• br Materials and methods br Results br Discussion

  2024-02-23

  

  Materials and methods Results Discussion Recently, we showed that stimulation of TRPM3 and TRPC6 channels triggers a signaling cascade leading to the activation of AP-1 [11], [12], [13], [15]. The objective of this study was to investigate whether stimulation of TRPV1 channels leads to an a

• Ketogenic diets are more effective

  2024-02-22

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

• br Author contributions br Acknowledgements We thank Dr Bob

  2024-02-22

  

  Author contributions Acknowledgements We thank Dr. Bob Hammer and the Transgenic Core Facility at UTSW for the generation of the transgenic lines, John Shelton and the Histology Core for assistance with histology and the UTSW Metabolic Core Unit for help in phenotyping. We acknowledge support

15082 records 128/1006 page Previous Next First page 上5页 126127128129130 下5页 Last page