• Introduction The intestinal tract of adult carries kg of

  2018-10-22

  

  Introduction The intestinal tract of adult carries 1–2kg of microbes. It is a common knowledge that pathogenic microbes could cause infectious diseases such as diarrheal, while others are associated with inflammatory and allergic diseases [1–3]. On the other hand, the majority of the gut microbes

• Research into embryogenesis and nervous system

  2018-10-22

  

  Research into embryogenesis and nervous system development has been instrumental to the identification of factors required for cell specification. Using information gleaned from these studies, many groups have developed induction protocols to instruct hESCs and iPSCs to become a variety of neural ce

• br Material and methods br Acknowledgment The authors would

  2018-10-22

  

  Material and methods Acknowledgment The authors would like to thank Mr. Chee Peng Ng (Institute of Molecular and Cell Biology, Singapore) for his help on the electron scanning microscope and Dr. William Birch (Institute of Materials Research and Engineering, Singapore) for his critical review

• Therefore a major goal remains to understand the complex cel

  2018-10-22

  

  Therefore, a major goal remains to understand the complex cellular and molecular network that controls HSC generation and expansion. In fact, HSCs that are mainly slow cycling (Wilson et al., 2008) and reside in the bone marrow during the entire life of an individual, are not generated there. They a

• The increasing number of studies focusing

  2018-10-22

  

  The increasing number of studies focusing on regenerative medicine and stem cell transplantation is being accompanied by the development of techniques using many types of nanoparticles. The combination of nanotechnology with stem cell research may be able to address some challenges in this research

• br Results br Discussion In this study

  2018-10-22

  

  Results Discussion In this study, we identified altogether 21 novel imprinted DMRs, including a novel class of intergenic DMRs, which reside in regions with no apparent imprinted ABT-263 in PSCs. This class of imprinted DMRs either may regulate genes in a tissue-specific manner, thus adding t

• PLX-4720 Although our work with BRCA mutant iPSCs

  2018-10-22

  

  Although our work with BRCA1 mutant iPSCs led to our investigation of PKC-theta upregulation in human breast tumors, future studies will be necessary to validate whether PKC-theta can be used as a biomarker or therapeutic target in BRCA1 mutant tumors. Because the frequency of BRCA1 mutations in pat

• br Materials and methods br Results br Discussion To evaluat

  2018-10-22

  

  Materials and methods Results Discussion To evaluate the effects of proNGF on NSC proliferation, we performed cell viability assay, BrdU incorporation assay and neurosphere assay. Our results showed that proNGF significantly reduced the total number of viable cells and the proportion of Brd

• In this study localization of the SSC population

  2018-10-22

  

  In this study, localization of the SSC population was determined by PGP 9.5 expression. PGP 9.5, also called ubiquitin C-terminal hydrolase L-1, is expressed in neuronal erk pathway and testes, and specific expression of PGP9.5 was identified in spermatogonia of day 8 and 16 mice, and PGP9.5 express

• br Materials and methods br Results br Discussion

  2018-10-20

  

  Materials and methods Results Discussion Strategies aiming at controlled divergence of ASCs to specific differentiated cell types essentially rely on prolonged culture in the presence of specific sets of growth factors and/or matrix proteins (Zuk et al., 2001). Specific culture conditions w

• In this study we were able to successfully delete

  2018-10-20

  

  In this study, we were able to successfully delete Klf5 from the Lgr5-expressing intestinal stem ibuprofen msds in adult mice. The short-term effect of Klf5 deletion in the intestinal and colonic stem cells was a gradual disappearance of Klf5 expression starting in the EGFP-positive stem cells and m

• br Acknowledgments We thank all the members of Wagers labora

  2018-10-20

  

  Acknowledgments We thank all the members of Wagers laboratory and E. Gussoni and E. Dzierzak for helpful discussions. We also thank A. Wakabayashi, G. Buruzula and J. LaVecchio at Joslin/HSCI Flow Cytometry Core for excellent flow cytometry support, funded in part by NIHP30 DK036836. This work wa

• PDGs possess a specific architecture and molecular

  2018-10-20

  

  PDGs possess a specific architecture and molecular signature that make them distinct from the pancreatic epithelium, instead resembling gastric stem cell glands. PDGs were also found to express and up-regulate TFF genes during injury. In the stomach TFF1 is normally found predominantly in the epithe

• In the present study we have used a set

  2018-10-20

  

  In the present study, we have used a set of OSCC cell lines and isolated the putative stem cell fraction (CD44highCD24low) along with CD44highCD24high and CD44lowCD24high (non-stem) sub-populations. These populations were subjected to various molecular and cellular assays to determine whether CD24 h

• br Materials and methods br Acknowledgments We thank Dr

  2018-10-20

  

  Materials and methods Acknowledgments We thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the reprogramming plasmids. Additionally, we would like to thank Tina Christoffersen and Birgit Kassow for skillful technical assistance. We acknowledge SHARE\'s Cross Faculty PhD Initiativ

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